Medical Research

Working Today for a Healthier Tomorrow

CAMRIS provides clinical research infrastructure, subject matter experts, technical support, research support, administrative support and program/project managers at multiple Military Medicine research facilities, both domestic and international. CAMRIS is actively working in five of the eight Naval Medical Research Unit laboratories across the globe.

Currently, CAMRIS provides services to:

  • The Naval Medical Research Unit – 3 (NAMRU-3) in Cairo, Egypt, where we manage the Operational Support and Investigational Research in Infection and Serology (OSIRIS) contract.
  • The Naval Medical Research Center (NMRC) in Silver Spring, Maryland, where we manage the Malaria Antigen Discovery (MAD) contract and Administrative, Management & Organization Support Services (AMOS II) contract.
  • The Walter Reed Army Institute of Research (WRAIR) in Silver Spring, Maryland, where we manage our Antimicrobial Resistance Monitoring and Research (ARMOR) contract.
  • The Naval Medical Research Unit - San Antonio (NAMRU-SA) in San Antonio, Texas, where we manage our Craniofacial Health and Restorative Medicine (CHARM) contract.
  • The Naval Medical Research Unit – Dayton (NAMRU-D) in Dayton, Ohio, where we support NAMRU-D’s research mission.
  • The Navy Hospital in San Diego, California to support the Antimicrobial Resistance Monitoring and Research (ARMOR) contract.
  • Travis Airforce Base in Travis AFB, California.
  • The Naval Health Research Center (NHRC) in San Diego, California.

CAMRIS has also provided services to:

  • The Naval Medical Research Unit – 3 (NAMRU-3) in Cairo, Egypt for the Ancillary Services to Support Epidemiological Research Targets (ASSERT) contract.
  • The Naval Medical Research Unit – Dayton (NAMRU-D) in Dayton, Ohio and the Naval Aerospace Medical Research Laboratory (NAMRL) in Pensacola, Florida for Support Services Contracts.
  • The Naval Health Research Center (NHRC) in San Diego, California.
  • The Naval Medical Research Unit in Peru (NAMRU-6) in Lima, Peru.
  • The Naval Medical Research Unit Pacific (NAMRU-2) in Phnom Penh, Cambodia.
  • The Naval Medical Center – Portsmouth (NMCP) in Portsmouth, Virginia.
  • The Wilford Hall Medical Center on Lackland Air Force Base in San Antonio, Texas.

Our Medical Research capabilities include:

  • Multicountry program and site management.
  • Phase II-IIIb clinical studies, from protocol design to clinical study report.
  • Clinical data management and statistical analysis.
  • Regulatory affairs and quality assurance.
  • Ethical review and institutional review board approvals.
  • Pharmacovigilance and medical monitoring.
  • Safety reviews.
  • Clinical research:
    • Toxicology research.
    • Biomedical research.
  • Medical modeling, simulation, and mission support.
  • Warfighter performance.
  • Behavioral sciences and epidemiology.
  • Deployment health research.
  • Military HIV/AIDS programs.
  • Respiratory and operational infectious diseases research.

Challenge

To provide expertise and conduct studies for the Naval Medical Research Center to develop a vaccine that kills malaria parasites after development in the liver but before they mature, reproduce, and spread into the blood infecting new red blood cells.

CAMRIS Approach

CAMRIS believes that efforts to combat malaria are most effective when implemented through an integrated combination of partnerships, research, and programs. CAMRIS partners to combat malaria and contribute to the health and well-being of communities worldwide have included:

  • Government agencies, including the U.S. Agency for International Development (USAID), the Naval Medical Research Center (NMRC), and the Naval Medical Research Unit Six (NAMRU-6).
  • Academic partners, e.g., Tulane University, Johns Hopkins University, and the University of California, San Francisco, among others.
  • Privately owned laboratories, clinical research organizations, biotechnology companies, and biopharmaceutical companies.
  • Philanthropically funded non-governmental organizations and public-private partnerships, such as the PATH Malaria Vaccine Initiative (MVI), for which CAMRIS currently leads antigen discovery research activities.

Currently, CAMRIS scientists are helping NMRC to characterize over 120 hypothetical Plasmodium falciparum pre-erythrocytic vaccine antigens (PEVA) to qualify for clinical development.

Result

CAMRIS researchers have identified several candidate antigens with potential for vaccine development and prospects for preclinical development. 

Challenge

The Naval Medical Research Unit Three (NAMRU – 3) needed an experienced contractor to provide scientific/technical (including administrative) services in support of medical research and development for the following specific topic areas:

  • International Emerging Infections Program (IEIP)/One Health.
  • Field Epidemiology Training Program (FETP).
  • Influenza.
  • Infection Prevention and Control.
  • International Health Regulations/Laboratory Capacity Building.
  • Infectious Diseases Syndromic Surveillance and Evaluation of Countermeasures.

CAMRIS Approach

Our OSIRIS staff identifies reoccurring and emergency diseases, develops and strengthens advanced characterization techniques, and develops and tests new technologies to improve viral pathogen detection and viral mutagenic prediction.

Oue work is compliant with all U.S. and host-country government labor laws in addition to the International Convention on Harmonization Guidelines for Good Clinical Practices, and Department of Defense and Department of Navy rules, regulations, and procedures. 

Result

As of today, we have achieved the following:

  • In conjunction with the Centers for Disease Control and Prevention (CDC), the International Emerging Infectious Disease Program, and the Egyptian Ministry of Health, provided a population-based surveillance to include acute respiratory infection (ARI), influenza-like illness (ILI), acute febrile illness (AFI), acute neurological infectious disease (AIND), and tuberculosis (TB) surveillance in Damanhour, the Nile Delta, covering approximately 750,000 residents.
  • As detailed in the table below, managed surveillance of severe acute respiratory infection (SARI) cases in Egypt and the Middle East.

                       

  • Provided healthcare-associated infection (HAI)/antimicrobial resistance (AMR) surveillance in Egypt at 61 hospitals, 216 ICUs, 2,035 ICU beds, and 8,500+HAI isolates.
  • Implemented hepatitis types A-, B-, C-, D-, and E-surveillance in 5 hospitals in Egypt, involving 6,043+ enrolled cases.
  • Completed WHO Annex 2 Lab Baseline assessments and clinical labs including 10 Governorates Central Public Health Labs (CPHL) in Egypt and both Jordanian Ministry of Health (MOH) and Ministry of Agriculture (MOAg) CPHLs.
  • As shown below, built the capacity of thousands of health professionals.

                                                                              Total Workforce Trained

                                       

Challenge

The Naval Medical Research Unit – San Antonio (NAMRU-SA) required an experienced contractor to conduct basic, applied, and translational research and to provide administrative support for the Carniofacial Health and Restorative Medicine (CHARM) directorate.

Our team works to improve the diagnosis, treatment, and prevention of oral, dental, and craniofacial diseases and injuries that affect U.S. Sailors and Marines; increase the drugs, technologies, and techniques available to clinicians for the treatment of antibiotic-resistant infections; and minimize the environmental impact of Naval Dentistry. 

CAMRIS Approach

Tasks include, but are not limited to, the following:

  • Develop and conduct protocol-driven scientific research.
  • Prepare research proposals, IACUC and IRB protocols, technical and final reports, and peer-reviewed manuscripts.
  • Analyze and evaluate data sets, develope presentation materials, and present research findings at scientific and professional meetings.
  • Support development of in vivo and in vitro model systems, data acquisition, and data analysis.
  • Prepare experimental subjects, set-up experimental equipment, and aid in training and development of experimental subjects for experimental procedures.
  • Provide technical and editorial support.
  • Develope new restorative dental materials.
  • Compile and analyze accounting records and other data to determine the financial resources required to implement programs.
  • Analyze monthly department budgeting and accounting reports to maintain obligation and expenditure controls.
  • Prepare regular and special budget reports.

Additionally, our senior scientists guide junior scientists and other staff members and fostere a team-first environment through team building activities. In carrying out tasks, our team employs operating controls to manage programmatic expenditures and adhere to approved protocols and applicable local, state, and federal regulations.

The CAMRIS technical approach is reinforced by accountability, timeliness, and compliance with established program objectives and benchmarks.

Result

Upon contract award, we quickly implemented our transition plan, successfully transitioning staff to the new task order. Our rapid engagement mitigated any potential disruptions in productivity, resulting in continuity of services.

As NAMRU-SA came to rely on CAMRIS, it entrusted us with additional positions, resulting in a contract modification, so we could build upon our initial successes and support the achievement of more complex scientific, technical, and administrative goals. 

Challenge

The Walter Reed Army Institute for Research (WRAIR), the largest U.S. Department of Defense-administered biomedical research facility, needed an experienced contractor to support the Antimicrobial Monitoring and Resistance (ARMoR) Program in responding to the rise of pathogenic microorganisms that resist drug treatment.

CAMRIS Approach

The CAMRIS team:

  • Centralizes and standardizes characterization and reporting of MDRO across the military medical treatment facility enterprise, including epidemiologic surveillance and collection of such organisms.
  • Issues periodic and special reports (such as outbreak investigation results) to enterprise clients and stakeholders, for enhancing infection control across the military healthcare system, including antibiograms.
  • Designs and deploys bioinformatics sequencing pipeline.
  • Implements high-throughput whole genome sequencing reference laboratory.
  • Conducts gene-deletion or mutagenis studies on bacterial isolates.
  • Designs novel polymerase chain reaction (PCR) and genomic assays and algorithms for detecting resistance determinants.

Throughout the execution of research, CAMRIS assures safety and compliance by employing biosafety policies and procedures regarding work involving infectious agents, toxic chemicals, carcinogens, animal and human tissues/fluids, flammable materials, and radiation hazards.

Result

CAMRIS provides WRAIR with quality personnel and the needed infrastructure to support antimicrobial research efforts, enhances healthcare for our service members and helps protect civilians, and manages and controls costs effectively for WRAIR while meeting and exceeding performance requirements.

Challenge

Work with the Naval Medical Research Unit – 3 (NAMRU-3) to help Ministries of Health (MOHs) to develop protocols and establish surveillance systems; build the capacity of local health organizations to prevent, detect, and respond to infectious disease outbreaks and report on hospital acquired infections; facilitate collaboration with government ministries and international agencies; and manage the logistics of handling and transferring cultures from participating hospitals to NAMRU-3.

CAMRIS Approach

Our staff provided program management, data management, and research support services for the NAMRU’s Research Science Directorate’s Global Disease Detection Response Program.

The cornerstones of our approach included accountability; timeliness of performance, services, and deliverables; and compliance with established performance objectives and benchmarks. Additionally, we ensured our work complied with international regulations, U.S. and host-country labor and tax laws, and Department of Defense and Department of Navy rules, regulations, and procedures.

Result

We supported efforts in the following countries and regions:

Egypt

  • Established central data hubs in the MOH and in the Ministry of Education (MOE).
  • Provided technical and managerial expertise for intensive care unit (ICU) surveillance of hospital-acquired infections (HAIs) and antimicrobial resistance (AMR) in 40 hospitals and surgical site infection (SSI) surveillance in 10 hospitals.
  • In support of furthering the country’s compliance with the World Health Organization’s International Health Regulations (IHR) 2005, identified five governorates to include in laboratory capacity building activities.
  • Built the capacities of 29 hospital microbiology laboratories to identify pathogens and conduct susceptibility testing of pathogens that cause hospital infections.
  • Supported data harmonization reporting across hospitals within the country.
  • Trained staff at 40 hospitals on how to manage data issues and to use personal digital assistants (PDAs).
  • Established infrastructure and supported three pilot hospitals to report data to the two central data hubs.
  • In Damanhour (the Delta region of Egypt), established a private physician network in support of capacity building and disease surveillance expansion to the private sector; and oversaw activities related to special research projects.

Jordan

  • Supported the MOH in establishing sentinel surveillance for severe acute respiratory illness (SARI) and HAI surveillance.
  • Built the capacity of and provided microbiology services to three hospital laboratories.
  • Ensured collection samples are preserved and transferred to NAMRU-3, and packaged per UN Economic and Social Council (ECOSOC), International Civil Aviation (ICAO) Organization, International Air Transport Association (IATA), and U.S. 42 Code of Federal Regulations (CFR) Part 72 regulations.

Eastern Mediterranean Region, North Africa, and West Africa

  • Provided technical expertise and consulted on the design, implementation, ad evaluation of public health programs concerning blood-borne pathogen transmission, respiratory infections, and the prevention and control of other infectious diseases.

Challenge

Provide research, technical, management, and administrative support to the Naval Aerospace Medical Research Laboratory (NAMRL) in Pensacola, Florida and Dayton, Ohio.

CAMRIS Approach

CAMRIS provided highly trained scientific, research and development, management, and administrative staff to conduct and support research and development, testing, and evaluations in aerospace medicine and related medical, psychological, and operational performance issues.

Result

CAMRIS provided NAMRL with highly skilled teams of scientists, engineers, program managers, information specialists, software engineers, and research, technical, and administrative assistants. The CAMRIS team met NAMRL’s need for experienced, qualified staff to support its research agenda, which covered a wide range of disciplines in human cognition, performance, and physiology, and included development and testing of new approaches to personnel training, physiological enhancement, pharmaceutical evaluations, and countermeasures.

Challenge

Service members face constant health challenges that diminish their ability to serve effectively and at their optimum capacity. CAMRIS works with its clients to identify the root causes of these health and safety threats.

CAMRIS Approach

Under the NAMRU-D Environmental Health Effects Directorate, the CAMRIS team supports multiple research protocols focused on determining safe exposure conditions for active service personnel, including:

  • Submarine atmospheres.
  • Risk assessment of burn pit emissions.
  • In vivo toxicity of jet fuels.
  • Jet fuel and noise-induced hearing loss.

Submarine atmosphere research studies are conducted to determine the outcome of health effects of female service members on submarines. The risk assessment of burn pit emissions research specifically focuses on toxicity and pulmonary health effects of deployed soldiers who were exposed to inhaling contaminates emitted from burn pits. Under the in vivo toxicity of jet fuels, the CAMRIS team is researching the effects of alternative fuels to establish safe exposure levels as they relate to physiological, biological, and genotoxic changes.

Result

The jet fuel and noise-induced hearing loss study found a direct relationship between the exposures of the JP-8 fuel vapors and hearing loss in rats.