Working Today for a Healthier Tomorrow
CAMRIS provides clinical research infrastructure, subject matter experts, technical support, research support, administrative support and program/project managers at multiple Military Medicine research facilities, both domestic and international.
Currently, CAMRIS provides services to:
- The Walter Reed Army Insitute of Research (WRAIR) in Silver Spring, Maryland, where we support the Entomology Services contract.
- The Air Force Medical Service (AFMS) in Falls Church, Virginia, where we manage the Total Exposure Health (TEH) contract.
- The Naval Medical Research Unit – Three (NAMRU-3) in Cairo, Egypt, where we manage the Operational Support and Investigational Research in Infection and Serology (OSIRIS) contract.
- The Naval Medical Research Center (NMRC) in Silver Spring, Maryland, where we manage the Malaria Antigen Discovery (MAD) II contract and Administrative, Management & Organization Support Services (AMOS) II contract.
- The Naval Medical Research Unit - San Antonio (NAMRU-SA) in San Antonio, Texas, where we manage our Craniofacial Health and Restorative Medicine (CHARM) contract.
- The Naval Medical Research Unit – Dayton (NAMRU-D) in Dayton, Ohio, where we support NAMRU-D’s research mission.
CAMRIS has also provided services to:
- The Walter Reed Army Institute of Research (WRAIR) in Silver Spring, Maryland for the Antimicrobial Resistance Monitoring and Research (ARMOR) contract.
- The Naval Health Research Center (NHRC) in San Diego, California.
- The Navy Hospital in San Diego, California to support the Antimicrobial Resistance Monitoring and Research (ARMOR) contract.
- The Naval Medical Research Unit – 3 (NAMRU-3) in Cairo, Egypt for the Ancillary Services to Support Epidemiological Research Targets (ASSERT) contract.
- The Naval Medical Research Unit – Dayton (NAMRU-D) in Dayton, Ohio and the Naval Aerospace Medical Research Laboratory (NAMRL) in Pensacola, Florida for Support Services Contracts.
- The Naval Medical Research Unit in Peru (NAMRU-6) in Lima, Peru.
- The Naval Medical Research Unit Pacific (NAMRU-2) in Phnom Penh, Cambodia.
- The Naval Medical Center – Portsmouth (NMCP) in Portsmouth, Virginia.
- The Wilford Hall Medical Center on Lackland Air Force Base in San Antonio, Texas.
Our Medical Research and Development capabilities include:
- Multicountry program and site management.
- Phase II-IIIb clinical studies, from protocol design to clinical study report.
- Clinical data management and statistical analysis.
- Regulatory affairs and quality assurance.
- Ethical review and institutional review board approvals.
- Pharmacovigilance and medical monitoring.
- Safety reviews.
- Clinical research:
- Toxicology research.
- Biomedical research.
- Medical modeling, simulation, and mission support.
- Warfighter performance.
- Behavioral sciences and epidemiology.
- Deployment health research.
- Military HIV/AIDS programs.
- Respiratory and operational infectious diseases research.
The Air Force Medical Support Agency (AFMSA) sought help in establishing the Total Exposure Health (TEH™) program; applying advances in tools and technologies (e.g., sensor systems, molecular technologies, and bioinformatics) to improve the collection of exposure science information by tracking chemical, biological, and physical stressors that are introduced into the environment; and studying the hazard potential of such stressors on the warfighter.
CAMRIS specialized staff work to actualize the following elements:
- Identify existing DoD-approved computer infrastructures projects with Authority to Operate for HIPPA-compliant PII/PHI aggregation and analysis.
- Identify, analyze, and track DoD Funds impact on TEH™.
- Identify training requirements for specialty fields clinical and non-clinical.
- Understand the landscape of existing initiatives within AFMS, the Surgeon General Office, and its stakeholders.
- Bring together a consortium of stakeholders with shared goals to develop relationships and combine resources, align deliverables, reduce redundancies, and identify gap and solutions.
- Identify and develop synergistic partnerships with other public, private, and academic sectors’ efforts.
- Establish the TEH™ program with sufficient structure to support the following:
- Leadership function.
- Policy and program support.
- Research and development.
- Program for training and education.
CAMRIS provides AFMSA with the on-site program expertise complimented by the unique subject matter expertise that is needed to successfully stand up the TEH™ office.
The Naval Medical Research Center (NMRC) required an experienced contractor to provide administrative, managerial, and organizational services in support of military medical research, budgets, surveys, and studies, and to conduct analyses on mission-related matters.
CAMRIS recruits, hires, and manages personnel who support NMRC in fulfilling its mission conducting medical research, development, testing, evaluation, and surveillance to enhance the readiness of Navy and Marine Corp service members. We address challenges through high-quality program management and communication services, collaborate directly with NMRC to make adjustments to our services provided as appropriate, and are committed to continuous improvement.
CAMRIS implements cost-control measures while providing NMRC with quality personnel to support its military medical research agenda.
The Naval Medical Research Unit Three (NAMRU – 3) needed an experienced contractor to provide scientific/technical (including administrative) services in support of medical research and development for the following specific topic areas:
- International Emerging Infections Program (IEIP)/One Health.
- Field Epidemiology Training Program (FETP).
- Infection Prevention and Control.
- International Health Regulations/Laboratory Capacity Building.
- Infectious Diseases Syndromic Surveillance and Evaluation of Countermeasures.
Our OSIRIS staff identify reoccurring and emergency diseases, develop and strengthen advanced characterization techniques, and develop and test new technologies to improve viral pathogen detection and viral mutagenic prediction.
Oue work is compliant with all U.S. and host-country government labor laws in addition to the International Convention on Harmonization Guidelines for Good Clinical Practices, and Department of Defense and Department of Navy rules, regulations, and procedures.
As of today, we have achieved the following:
- In conjunction with the Centers for Disease Control and Prevention (CDC), the International Emerging Infectious Disease Program, and the Egyptian Ministry of Health, provided a population-based surveillance to include acute respiratory infection (ARI), influenza-like illness (ILI), acute febrile illness (AFI), acute neurological infectious disease (AIND), and tuberculosis (TB) surveillance in Damanhour, the Nile Delta, covering approximately 750,000 residents.
- As detailed in the table below, managed surveillance of severe acute respiratory infection (SARI) cases in Egypt and the Middle East.
- Provided healthcare-associated infection (HAI)/antimicrobial resistance (AMR) surveillance in Egypt at 61 hospitals, 216 ICUs, 2,035 ICU beds, and 8,500+HAI isolates.
- Implemented hepatitis types A-, B-, C-, D-, and E-surveillance in 5 hospitals in Egypt, involving 6,043+ enrolled cases.
- Completed WHO Annex 2 Lab Baseline assessments and clinical labs including 10 Governorates Central Public Health Labs (CPHL) in Egypt and both Jordanian Ministry of Health (MOH) and Ministry of Agriculture (MOAg) CPHLs.
- As shown below, built the capacity of thousands of health professionals.
Total Workforce Trained
The Naval Medical Research Unit – San Antonio (NAMRU-SA) required an experienced contractor to conduct basic, applied, and translational research and to provide administrative support for the Craniofacial Health and Restorative Medicine (CHARM) directorate.
Our team works to improve the diagnosis, treatment, and prevention of oral, dental, and craniofacial diseases and injuries that affect U.S. Sailors and Marines; increase the drugs, technologies, and techniques available to clinicians for the treatment of antibiotic-resistant infections; and minimize the environmental impact of Naval Dentistry.
Tasks include, but are not limited to, the following:
- Develop and conduct protocol-driven scientific research.
- Prepare research proposals, IACUC and IRB protocols, technical and final reports, and peer-reviewed manuscripts.
- Analyze and evaluate data sets, develope presentation materials, and present research findings at scientific and professional meetings.
- Support development of in vivo and in vitro model systems, data acquisition, and data analysis.
- Prepare experimental subjects, set-up experimental equipment, and aid in training and development of experimental subjects for experimental procedures.
- Provide technical and editorial support.
- Develope new restorative dental materials.
- Compile and analyze accounting records and other data to determine the financial resources required to implement programs.
- Analyze monthly department budgeting and accounting reports to maintain obligation and expenditure controls.
- Prepare regular and special budget reports.
Additionally, our senior scientists guide junior scientists and other staff members and fostere a team-first environment through team building activities. In carrying out tasks, our team employs operating controls to manage programmatic expenditures and adheres to approved protocols and applicable local, state, and federal regulations.
The CAMRIS technical approach is reinforced by accountability, timeliness, and compliance with established program objectives and benchmarks.
Upon contract award, we quickly implemented our transition plan, successfully transitioning staff to the new task order. Our rapid engagement mitigated any potential disruptions in productivity, resulting in continuity of services.
As NAMRU-SA came to rely on CAMRIS, it entrusted us with additional positions, resulting in a contract modification, so we could build upon our initial successes and support the achievement of more complex scientific, technical, and administrative goals.
The Walter Reed Army Institute for Research (WRAIR), the largest U.S. Department of Defense-administered biomedical research facility, needed an experienced contractor to support the Antimicrobial Monitoring and Resistance (ARMoR) Program in responding to the rise of pathogenic microorganisms that resist drug treatment.
The CAMRIS team:
- Centralizes and standardizes characterization and reporting of MDRO across the military medical treatment facility enterprise, including epidemiologic surveillance and collection of such organisms.
- Issues periodic and special reports (such as outbreak investigation results) to enterprise clients and stakeholders, for enhancing infection control across the military healthcare system, including antibiograms.
- Designs and deploys bioinformatics sequencing pipeline.
- Implements high-throughput whole genome sequencing reference laboratory.
- Conducts gene-deletion or mutagenis studies on bacterial isolates.
- Designs novel polymerase chain reaction (PCR) and genomic assays and algorithms for detecting resistance determinants.
Throughout the execution of research, CAMRIS assures safety and compliance by employing biosafety policies and procedures regarding work involving infectious agents, toxic chemicals, carcinogens, animal and human tissues/fluids, flammable materials, and radiation hazards.
CAMRIS provides WRAIR with quality personnel and the needed infrastructure to support antimicrobial research efforts, enhances healthcare for our service members and helps protect civilians, and manages and controls costs effectively for WRAIR while meeting and exceeding performance requirements.
Work with the Naval Medical Research Unit – 3 (NAMRU-3) to help Ministries of Health (MOHs) to develop protocols and establish surveillance systems; build the capacity of local health organizations to prevent, detect, and respond to infectious disease outbreaks and report on hospital acquired infections; facilitate collaboration with government ministries and international agencies; and manage the logistics of handling and transferring cultures from participating hospitals to NAMRU-3.
Our staff provided program management, data management, and research support services for the NAMRU’s Research Science Directorate’s Global Disease Detection Response Program.
The cornerstones of our approach included accountability; timeliness of performance, services, and deliverables; and compliance with established performance objectives and benchmarks. Additionally, we ensured our work complied with international regulations, U.S. and host-country labor and tax laws, and Department of Defense and Department of Navy rules, regulations, and procedures.
We supported efforts in the following countries and regions:
- Established central data hubs in the MOH and in the Ministry of Education (MOE).
- Provided technical and managerial expertise for intensive care unit (ICU) surveillance of hospital-acquired infections (HAIs) and antimicrobial resistance (AMR) in 40 hospitals and surgical site infection (SSI) surveillance in 10 hospitals.
- In support of furthering the country’s compliance with the World Health Organization’s International Health Regulations (IHR) 2005, identified five governorates to include in laboratory capacity building activities.
- Built the capacities of 29 hospital microbiology laboratories to identify pathogens and conduct susceptibility testing of pathogens that cause hospital infections.
- Supported data harmonization reporting across hospitals within the country.
- Trained staff at 40 hospitals on how to manage data issues and to use personal digital assistants (PDAs).
- Established infrastructure and supported three pilot hospitals to report data to the two central data hubs.
- In Damanhour (the Delta region of Egypt), established a private physician network in support of capacity building and disease surveillance expansion to the private sector; and oversaw activities related to special research projects.
- Supported the MOH in establishing sentinel surveillance for severe acute respiratory illness (SARI) and HAI surveillance.
- Built the capacity of and provided microbiology services to three hospital laboratories.
- Ensured collection samples are preserved and transferred to NAMRU-3, and packaged per UN Economic and Social Council (ECOSOC), International Civil Aviation (ICAO) Organization, International Air Transport Association (IATA), and U.S. 42 Code of Federal Regulations (CFR) Part 72 regulations.
Eastern Mediterranean Region, North Africa, and West Africa
- Provided technical expertise and consulted on the design, implementation, ad evaluation of public health programs concerning blood-borne pathogen transmission, respiratory infections, and the prevention and control of other infectious diseases.
Provide research, technical, management, and administrative support to the Naval Aerospace Medical Research Laboratory (NAMRL) in Pensacola, Florida and Dayton, Ohio.
CAMRIS provided highly trained scientific, research and development, management, and administrative staff to conduct and support research and development, testing, and evaluations in aerospace medicine and related medical, psychological, and operational performance issues.
CAMRIS provided NAMRL with highly skilled teams of scientists, engineers, program managers, information specialists, software engineers, and research, technical, and administrative assistants. The CAMRIS team met NAMRL’s need for experienced, qualified staff to support its research agenda, which covered a wide range of disciplines in human cognition, performance, and physiology, and included development and testing of new approaches to personnel training, physiological enhancement, pharmaceutical evaluations, and countermeasures.
Service members face constant health challenges that diminish their ability to serve effectively and at their optimum capacity. CAMRIS works with its clients to identify the root causes of these health and safety threats.
Under the NAMRU-D Environmental Health Effects Directorate, the CAMRIS team supports multiple research protocols focused on determining safe exposure conditions for active service personnel, including:
- Submarine atmospheres.
- Risk assessment of burn pit emissions.
- In vivo toxicity of jet fuels.
- Jet fuel and noise-induced hearing loss.
Submarine atmosphere research studies are conducted to determine the outcome of health effects of female service members on submarines. The risk assessment of burn pit emissions research specifically focuses on toxicity and pulmonary health effects of deployed soldiers who were exposed to inhaling contaminates emitted from burn pits. Under the in vivo toxicity of jet fuels, the CAMRIS team is researching the effects of alternative fuels to establish safe exposure levels as they relate to physiological, biological, and genotoxic changes.
The jet fuel and noise-induced hearing loss study found a direct relationship between the exposures of the JP-8 fuel vapors and hearing loss in rats.